Alcohol, Cell Membranes, and Signal Transduction in Brain by Christopher D. Stubbs, Emanuel Rubin (auth.), Christer

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By Christopher D. Stubbs, Emanuel Rubin (auth.), Christer Alling, Ivan Diamond, Steven W. Leslie, Grace Y. Sun, W. Gibson Wood (eds.)

Alcohol abuse and alcoholism are overseas difficulties whose bills cost-efficient­ ly, psychologically and medically were good documented. Alcohol is a different drug in that the results of over the top use may have a deleterious impact on such a lot if no longer all organs of the physique. The mind is without doubt one of the organs most influenced by means of over the top alcohol intake. results at the mind might be noticeable in cognitive functionality, mind constitution and neurochemistry. during the last few years, there were major advances made in knowing how alcohol impacts mind neurochemistry. This ebook examines 4 significant parts, i. e. , membrane lipids, receptors and ion channels, moment messengers, and gene expression, the place major developments were made. The ebook is split into 4 sections in line with the 4 significant components. In every one part, information are tested that hide various techniques from in vitro to in vivo experiences. The part on membrane lipids contains contemporary advancements in how ethanol impacts membrane ldl cholesterol domain names, polyunsaturated fatty acids, the reason and results of phosphatidylethanol formation, and the modulation of membrane protein functionality by way of lipid-protein interplay. the second one part includes chapters on NMDA and 5-HT3 receptors, together with new points on alcohol neurotoxicity and the molecular heterogeneity that could underlie modifications in alcohol sensitivity in addition to chapters on GABA-gated chloride flux, and calcium channels.

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