Advances in Prostaglandin, Leukotriene, and other Bioactive by Jeffrey M. Drazen (auth.), Zeliha Yazici, Giancarlo C.

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By Jeffrey M. Drazen (auth.), Zeliha Yazici, Giancarlo C. Folco, Jeffrey M. Drazen, Santosh Nigam, Takao Shimizu (eds.)

This quantity, the complaints of the twelfth overseas convention on Advances in Prostaglandin, Leukotriene and different Bioactive Lipid study: uncomplicated technological know-how and scientific purposes, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid learn with designated recognition to melanoma, cardiovascular illnesses, gastrointestinal ailments and breathing illnesses. particular themes lined comprise the position of leukotrienes and lipoxins in irritation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.

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Extra resources for Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research: Basic Science and Clinical Applications

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Pharmacological evidence that human intralobar airways do not contain different receptors that mediate contractions to leukotriene C4 and leukotriene 04. J Phannacol Exp Ther 1986; 237: 558-62. Tudhope SR, Cuthbert NJ, Abram TS, Jennings MA, Maxey RJ, Thompson AM, Norman P, Gardiner P1. BAY u9773, a novel antagonist of cysteinyl-Ieukotrienes with activity against two receptor subtypes. Eur J Phannacol1994; 264: 317-23. Bilek M, Nore! X, Walch L, Gascard J, Mazmanian G, Dahlen S, Brink C. Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-Ieukotrienes.

Lung function improvement in asthma with a cysteinylleukotriene receptor antagonist. Lancet 1991; 337:I062-1063. Israel E, Rubin P, Kemp JP, Grossman J, Pierson WE, Siegel SC et al. The effect of inhibition of 5-lipoxygenase by zileuton in mild to moderate asthma. Ann Intern Med 1993; 119:1059-1066. Malmstrom K, Rodriguez-Gomez G, Guerra J, Villaran C, Pineiro A, Wei LX et al. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized controlled trial. Ann Int Med 1999; 130:487-495.

Additional experiments on the influence of LTD4 on progenitor cell migration demonstrated that LTD4 had a sustained effect on the cytoskeleton of CD34+ cells, and that these cells responded by chemotaxis towards a gradient ofLTD4 [6]. Since HPC trafficking is regulated at least in part at the level of the bone marrow endothelium, a series of in vitro assays was set up to further characterize potential effects of LTD4 on progenitor cell adhesion. 6 % (mean ± SEM). Similar results were seen on primary bone marrow endothelium isolated from donor aspirates, immobilized VCAM-l, and fibronectin.

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